Sodium Bicarbonate → HCID 67364572, compound

HRID 1916618Notes

Reaction equation

HRID 1916618 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]([NH:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:6][CH:7]=1.[C:17]([O-])(O)=O.[Na+]>C(O)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[N:8]([CH2:9][CH2:10][N:11]3[CH2:12][CH2:13][CH2:14][CH2:15]3)[CH:17]=[N:16][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 62642302HCID 62642302, compound

Product 1

HCID 67364572HCID 67364572, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 904 mg (3.18 mmol) 4-bromo-N1-(2-pyrrolidin-1-yl-ethyl)-benzene-1,2-diamine in 5 mL formic acid is refluxed for 1.5 h. It is made alkaline with semisaturated NaHCO3 solution and extracted twice with 70 mL EtOAc. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac.

Workup

  1. extractionextracted twice with 70 mL EtOAc
  2. dry with materialThe organic phase is dried over MgSO4

Sources & evidence

ORD record
ord-4161efd17ccc48dfa08661c2e4ad591c
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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