Sodium Bicarbonate → HCID 67362954, compound

HRID 1916622Notes

Reaction equation

HRID 1916622 reaction equation
[CH3:1][NH:2][C:3]1[C:4]([NH2:15])=[CH:5][C:6]([CH2:9][N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:7][CH:8]=1.[C:16]([O-])(O)=O.[Na+]>C(O)=O>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][C:6]([CH2:9][N:10]3[CH2:11][CH2:12][CH2:13][CH2:14]3)=[CH:5][C:4]=2[N:15]=[CH:16]1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 85969746HCID 85969746, compound

Product 1

HCID 67362954HCID 67362954, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 850 mg (4.14 mmol) N1-methyl-4-pyrrolidin-1-ylmethyl-benzene-1,2-diamine in 4 mL formic acid is refluxed for 1.5 h. It is made alkaline with 250 mL semisaturated NaHCO3 solution and extracted twice with 70 mL EtOAc. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac.

Workup

  1. extractionextracted twice with 70 mL EtOAc
  2. dry with materialThe organic phase is dried over MgSO4

Sources & evidence

ORD record
ord-1de7f51983ae4f0498f28d2e5bcd3894
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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