Acetone → HCID 12118321, compound

HRID 1916642Notes

Reaction equation

HRID 1916642 reaction equation
CC(C)=O.[Br:5][C:6]1[N:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.Cl.Cl[CH2:15][CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1>C(#N)C>[Br:5][C:6]1[CH:7]=[CH:8][C:9]([O:12][CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:10][N:11]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 816681-(2-Chloroethyl)pyrrolidine hydrochlorideHCID 27628652-Bromo-5-hydroxypyridine

Product 1

HCID 12118321HCID 12118321, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The product is obtained analogously to Example 3.1 e (1:1 mixture of acetone:acetonitrile instead of DMF) from 3.90 g (22.4 mmol) 6-bromo-pyridin-3-ol and 4.25 g (25.0 mmol) N-(2-chloroethyl)-pyrrolidine hydrochloride.

Workup

  1. customThe product is obtained analogously to Example 3.1 e (

Sources & evidence

ORD record
ord-4fdcfec1ae614544b0c9511f4fe90af3
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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