1-(2-(4-Iodophenoxy)ethyl)pyrrolidine → 3-(4-Chloro-phenyl)-6-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylethynyl]-pyridazine

HRID 1916672Notes

Reaction equation

I[C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[N:24]=[N:25][C:26]([C:29]#[CH:30])=[CH:27][CH:28]=2)=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[N:24]=[N:25][C:26]([C:29]#[C:30][C:2]3[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]4[CH2:13][CH2:12][CH2:11][CH2:10]4)=[CH:4][CH:3]=3)=[CH:27][CH:28]=2)=[CH:21][CH:22]=1

Participants

Reactant 2

HCID 219591661-(2-(4-Iodophenoxy)ethyl)pyrrolidine

HCID 859696873-(4-Chloro-phenyl)-6-ethynyl-pyridazine

Product 1

HCID 598357993-(4-Chloro-phenyl)-6-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylethynyl]-pyridazine

Procedure

Prepared according to general working method I from 1-[2-(4-iodo-phenoxy)-ethyl]-pyrrolidine (200 mg, 0.63 mmol) and 3-(4-chloro-phenyl)-6-ethynyl-pyridazine (135 mg, 0.63 mmol).

Workup

customPrepared

Sources & evidence

ORD record: ord-ddcc9b37e11d48eb925aa6033570903d
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618132B2

Reaction notes

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