Hydrochloric Acid → HCID 69074784, compound

HRID 1916699Notes

Reaction equation

HRID 1916699 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:15]#[C:16][C:17]3[CH:35]=[CH:34][C:20]([O:21][CH2:22][CH2:23][N:24]4[CH2:29][CH2:28][CH:27]([CH2:30][N:31]([CH3:33])[CH3:32])[CH2:26][CH2:25]4)=[CH:19][CH:18]=3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1>C(Cl)Cl.CC(C)=O>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([C:15]#[C:16][C:17]3[CH:18]=[CH:19][C:20]([O:21][CH2:22][CH2:23][N:24]4[CH2:29][CH2:28][CH:27]([CH2:30][N:31]([CH3:33])[CH3:32])[CH2:26][CH2:25]4)=[CH:34][CH:35]=3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59835862HCID 59835862, compound

Product 1

HCID 69074784HCID 69074784, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 6344DichloromethaneSolvent

Procedure

Saturated ethereal HCl solution is added to a solution of 15 mg (0.03 mmol) [1-(2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy}-ethyl)-piperidin-4-ylmethyl]-dimethyl-amine (Example 4.41) in 6 mL DCM and 4 mL acetone until no more precipitate is formed during the addition. The salt formed is suction filtered in a nitrogen current and dried.

Workup

  1. customis formed during the addition
  2. customThe salt formed
  3. filtrationfiltered in a nitrogen current
  4. customdried

Sources & evidence

ORD record
ord-0bc455db868b4975b6c037a847b66bae
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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