2-(4-Iodo-2-methyl-phenoxy)-ethanol → 2-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-methylphenoxy}ethanol

HRID 1916701Notes

Reaction equation

HRID 1916701 reaction equation
I[C:2]1[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[C:4]([CH3:12])[CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[CH:22][C:23]([C:26]#[CH:27])=[N:24][CH:25]=2)=[CH:16][CH:15]=1>N1CCCCC1>[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:21]=[CH:22][C:23]([C:26]#[C:27][C:2]3[CH:11]=[CH:10][C:5]([O:6][CH2:7][CH2:8][OH:9])=[C:4]([CH3:12])[CH:3]=3)=[N:24][CH:25]=2)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 40551152-(4-Iodo-2-methyl-phenoxy)-ethanolHCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridine

Product 1

HCID 673624362-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-methylphenoxy}ethanol

Reagents, catalysts & solvents 1

HCID 8082PiperidineSolvent

Procedure

Prepared analogously to Example 4b from 380 mg (1.37 mmol) 2-(4-iodo-2-methyl-phenoxy)-ethanol and 292 mg (1.37 mmol) 5-(4-chloro-phenyl)-2-ethynyl-pyridine in 38 mL piperidine.

Sources & evidence

ORD record
ord-b64eb090481a486a872c44fd308d2dad
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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