反应详情

A solution of 110 mg (0.25 mmol) 2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-2-methyl-phenoxy}-ethyl methanesulphonate in 2.11 mL (25 mmol) pyrrolidine is heated to 70° C. for 3 h. The mixture is evaporated down i. vac., the residue is combined with water, extracted exhaustively with DCM and the organic phase is dried over Na2SO4. After the desiccant and solvent have been eliminated and after recrystallisation from EtOH the desired product is obtained.

1. customThe mixture is evaporated down i
2. extractionextracted exhaustively with DCM
3. dry with materialthe organic phase is dried over Na2SO4
4. customafter recrystallisation from EtOH the desired product
5. customis obtained