HCID 10635707, compound → 6-Bromoquinolin-2(1H)-one

HRID 1916749Notes

Reaction equation

HRID 1916749 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:15])/[CH:10]=[CH:11]/OCC)=[CH:4][CH:3]=1>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[NH:8][C:9](=[O:15])[CH:10]=[CH:11]2

Participants

3

Reactant 1

HCID 10635707HCID 10635707, compound

Product 1

HCID 123789436-Bromoquinolin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

37.8 g (0.14 mol) (E)-N-(4-bromo-phenyl)-3-ethoxy-acrylamide are added batchwise to 200 mL concentrated sulphuric acid and stirred for 2 h at RT. Then the reaction mixture is poured into ice water, the precipitate is filtered off and washed with water. The solid is dried at 70° C. in the drying cupboard.

Workup

  1. filtrationthe precipitate is filtered off
  2. washwashed with water
  3. customThe solid is dried at 70° C. in the drying cupboard

Sources & evidence

ORD record
ord-053f5ee3423049e3b6ff14ee814fdd79
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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