HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1916751Generated: October 29, 2026
Ammonia → 2-Bromo-6-(4-chloro-phenyl)-quinoline
https://huagongshe.com/reaction/1916751
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Phosphorus oxybromide | HCID 24613 | — |
| Reactant | 6-(4-chloro-phenyl)-1H-quinolin-2-one | HCID 67364248 | — |
| Product | 2-Bromo-6-(4-chloro-phenyl)-quinoline | HCID 85969692 | — |
Reaction Steps
50 g (0.174 mol) phosphorus oxybromide are heated to 65° C., combined with 10 g (0.039 mol) 6-(4-chloro-phenyl)-1H-quinolin-2-one and heated to 110° C. for 3 h. The reaction mixture is then poured onto ice water and made alkaline with ammonia solution. The precipitate is filtered off and dried in the drying cupboard at 60° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618132B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-03bc9d1fb16b49b097b3d5102ab1053c |
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| Source note | uspto-grants-2013_12 |
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