1-(2-Chloroethyl)pyrrolidine hydrochloride → 1-[2-(3-Ethynyl-phenoxy)-ethyl]-pyrrolidine

HRID 1916758Notes

Reaction equation

HRID 1916758 reaction equation
Cl.Cl[CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1.[C:10]([C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[CH:16][CH:17]=1)#[CH:11]>>[C:10]([C:12]1[CH:13]=[C:14]([CH:15]=[CH:16][CH:17]=1)[O:18][CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][CH2:6]1)#[CH:11]

Participants

3

Reactant 2

HCID 816681-(2-Chloroethyl)pyrrolidine hydrochlorideHCID 139144m-Ethynylphenol

Product 1

HCID 859695581-[2-(3-Ethynyl-phenoxy)-ethyl]-pyrrolidine

Procedure

Prepared analogously to Example 18a from 1-(2-chloro-ethyl)-pyrrolidine-hydrochloride and 3-ethynyl-phenol.

Sources & evidence

ORD record
ord-cea7530cc3004b28b8367d9d83ea91a1
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

Loading…