5-Ethynyl-2-pyrrolidin-1-ylmethyl-benzoxazole → 6-(4-Chloro-phenyl)-2-(2-pyrrolidin-1-ylmethyl-benzoxazol-5-ylethynyl)-quinoline

HRID 1916764Notes

Reaction equation

HRID 1916764 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([CH2:11][N:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)=[N:8][C:7]=2[CH:17]=1)#[CH:2].Br[C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[C:24]([C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[CH:25]=2)[N:20]=1>>[Cl:35][C:32]1[CH:31]=[CH:30][C:29]([C:24]2[CH:25]=[C:26]3[C:21](=[CH:22][CH:23]=2)[N:20]=[C:19]([C:2]#[C:1][C:3]2[CH:4]=[CH:5][C:6]4[O:10][C:9]([CH2:11][N:12]5[CH2:16][CH2:15][CH2:14][CH2:13]5)=[N:8][C:7]=4[CH:17]=2)[CH:28]=[CH:27]3)=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 859695885-Ethynyl-2-pyrrolidin-1-ylmethyl-benzoxazoleHCID 859696922-Bromo-6-(4-chloro-phenyl)-quinoline

Product 1

HCID 598358096-(4-Chloro-phenyl)-2-(2-pyrrolidin-1-ylmethyl-benzoxazol-5-ylethynyl)-quinoline

Procedure

Prepared analogously to Example 18d from 5-ethynyl-2-pyrrolidin-1-ylmethyl-benzoxazole and 2-bromo-6-(4-chloro-phenyl)-quinoline.

Sources & evidence

ORD record
ord-4685ad6c675d498986e77673de79d131
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

Loading…