Acetic Anhydride → HCID 59835762, compound

HRID 1916769Notes

Reaction equation

HRID 1916769 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]#[C:22][C:23]3[CH:24]=[CH:25][C:26]([O:30][CH2:31][CH2:32][N:33]4[CH2:37][CH2:36][CH2:35][CH2:34]4)=[C:27]([NH2:29])[CH:28]=3)=[N:19][CH:20]=2)=[CH:11][CH:10]=1>C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]#[C:22][C:23]3[CH:24]=[CH:25][C:26]([O:30][CH2:31][CH2:32][N:33]4[CH2:34][CH2:35][CH2:36][CH2:37]4)=[C:27]([NH:29][C:1](=[O:3])[CH3:2])[CH:28]=3)=[N:19][CH:20]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 59835738HCID 59835738, compound

Product 1

HCID 59835762HCID 59835762, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

16 μL (170 μmol) acetic anhydride are added to a solution of 35 mg (84 μmol) 5-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-2-(2-pyrrolidin-1-yl-ethoxy)-phenylamine in 2 mL DCM and the reaction mixture is stirred overnight at RT and then purified by chromatography on silica gel (gradient: EtOAc to EtOAc/MeOH/NH3 7:3:0.3) without any further working up

Workup

  1. custompurified by chromatography on silica gel (gradient: EtOAc to EtOAc/MeOH/NH3 7:3:0.3) without

Sources & evidence

ORD record
ord-c50f6e32596444bb88406bf9cd2aface
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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