Hydrochloric Acid → HCID 67953926, compound

HRID 1916845Notes

Reaction equation

HRID 1916845 reaction equation
C(OC([N:8]([C:22]1[N:23]=[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]2[C:30]=1[CH3:31])[S:9]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)(=[O:11])=[O:10])=O)(C)(C)C.Cl>O1CCOCC1.CCOCC>[CH3:31][C:30]1[N:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]2=[N:23][C:22]=1[NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)(=[O:11])=[O:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67966854HCID 67966854, compound

Product 1

HCID 67953926HCID 67953926, compoundYield 71.4%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

To compound 1-F (0.188 g, 0.422 mmol) was added 4N HCl in dioxane (6 mL) and the reaction mixture was stirred at room temperature for 18 h. The reaction was diluted with ether, filtered, and the solid washed with ether and dried in vacuo to afford compound 1-G as a white solid (0.104 g, 65%). 1H-NMR (CD3OD): δ 8.53-8.55 (d, 1H), 8.21-8.23 (d, 2H), 7.99-8.03 (m, 1H), 7.84-7.86 (d, 2H), 7.51-7.55 (m, 1H), 3.97 (s, 3H), 2.07 (s, 9H); MS: m/z 346.0 (MH+).

Workup

  1. filtrationfiltered
  2. washthe solid washed with ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-0b26342a554f476598d682df25e9c569
Source dataset
uspto-grants-2013_12
Patent number
US08618150B2

Reaction notes

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