Hydrochloric Acid → HCID 67954005, compound

HRID 1916847Notes

Reaction equation

HRID 1916847 reaction equation
C(OC([N:8]([C:22]1[N:23]=[C:24]2[C:29]([CH3:30])=[CH:28][CH:27]=[CH:26][N:25]2[C:31]=1[CH3:32])[S:9]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)(=[O:11])=[O:10])=O)(C)(C)C.Cl>O1CCOCC1>[CH3:32][C:31]1[N:25]2[CH:26]=[CH:27][CH:28]=[C:29]([CH3:30])[C:24]2=[N:23][C:22]=1[NH:8][S:9]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67966859HCID 67966859, compound

Product 1

HCID 67954005HCID 67954005, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To compound 2-C (0.693 g, 1.51 mmol) was added 4N HCl in dioxane (30 mL) and the reaction mixture was stirred at room temperature for 18 h. The solvent was evaporated under reduced pressure, the solid triturated with ether, filtered, and the solid washed with ether and dried in vacuo to afford compound 2-D as a white solid (0.601 g, 100%). MS: m/z 360.1 (MH+).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe solid triturated with ether
  3. filtrationfiltered
  4. washthe solid washed with ether
  5. customdried in vacuo
  6. customto afford compound 2-D as a white solid (0.601 g, 100%)

Sources & evidence

ORD record
ord-9a504a0c153a4b2db1d7eb8c07d9365e
Source dataset
uspto-grants-2013_12
Patent number
US08618150B2

Reaction notes

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