Trifluoroacetic acid → HCID 67953983, compound

HRID 1916861Notes

Reaction equation

HRID 1916861 reaction equation
C(OC([N:8]([C:18]1[N:19]=[C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][N:21]2[C:30]=1[CH3:31])[S:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:11])=[O:10])=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:31][C:30]1[N:21]2[CH:22]=[C:23]([C:26]([F:27])([F:28])[F:29])[CH:24]=[CH:25][C:20]2=[N:19][C:18]=1[NH:8][S:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67953948HCID 67953948, compound

Product 1

HCID 67953983HCID 67953983, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 10-F (0.066 g, 0.084 mmol) in methylene chloride (2 mL) was added trifluoroacetic acid (1 mL) and the resulting mixture was stirred at room temperature overnight. The solvent was evaporated in vacuo and the crude product, isolated as a light yellow oil, was used in the next step without further purification; MS m/z (M+H+) 356.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-d09c36c7c0d24f03ac93bc82bd766af2
Source dataset
uspto-grants-2013_12
Patent number
US08618150B2

Reaction notes

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