Trifluoroacetic acid → HCID 67954058, compound

HRID 1916866Notes

Reaction equation

HRID 1916866 reaction equation
C(OC([N:8]([C:18]1[N:19]=[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]2[C:26]=1[CH:27]1[CH2:29][CH2:28]1)[S:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:11])=[O:10])=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH:27]1([C:26]2[N:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]3=[N:19][C:18]=2[NH:8][S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:10])=[O:11])[CH2:29][CH2:28]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67954050HCID 67954050, compound

Product 1

HCID 67954058HCID 67954058, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 12-E (0.083 g, 0.2 mmol) in methylene chloride (2 mL) was added trifluoroacetic acid (1 mL) and the resulting mixture was stirred at room temperature for 5 h. The solvent was evaporated in vacuo and the crude product, isolated as a light yellow oil, was used in the next step without further purification; MS m/z (M+H+) 314.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-7564109c7bc442a3be75ed1014d0a429
Source dataset
uspto-grants-2013_12
Patent number
US08618150B2

Reaction notes

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