Methanol → HCID 67953996, compound

HRID 1916873Notes

Reaction equation

HRID 1916873 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH3:19])=[C:9]([NH:11]C(=O)OC(C)(C)C)[N:10]=2)[CH:7]=1.CO>Cl.O1CCOCC1>[ClH:1].[NH2:11][C:9]1[N:10]=[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]2[C:8]=1[CH3:19]

Participants

5

Reactant 2

HCID 887MethanolHCID 67966902HCID 67966902, compound

Product 1

HCID 67953996HCID 67953996, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

Compound 15-B (0.500 g, 1.77 mmol) was dissolved in 4N HCl in dioxane (17.75 mL) and methanol (12 mL) and the reaction mixture was stirred for 3 h at room temperature. The solvent was evaporated in vacuo to give compound 16-A as a light yellow solid; MS m/z (M+H+) 182.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-ec562473e806472f9c82e2dd50e8804a
Source dataset
uspto-grants-2013_12
Patent number
US08618150B2

Reaction notes

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