Dichloromethane → 2-Chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 191690Notes

Reaction equation

HRID 191690 reaction equation
[CH3:31][CH2:32][N:33]([CH2:34][CH3:35])[CH2:36][CH3:37].[CH:24]1([S:27](=[O:28])(=[O:29])[Cl:30])[CH2:25][CH2:26]1.[Cl:1][c:2]1[n:3][c:4]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[s:10]2.[Cl:38][CH2:39][Cl:40]>>[Cl:1][c:2]1[n:3][c:4]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([S:27]([CH:24]3[CH2:25][CH2:26]3)(=[O:28])=[O:29])[CH2:16][CH2:17]1)[s:10]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 2760919Cyclopropanesulfonyl chlorideHCID 574940574-(2-Chloro-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Product 1

HCID 866192722-Chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-f20a6f7b40ee43d59a82bde50fa657fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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