5-(4-Carboxyphenyl)-2-hydroxypyridine → N-[2-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide

HRID 1916938Notes

Reaction equation

HRID 1916938 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[O:20]=[C:21]1[NH:26][CH:25]=[C:24]([C:27]2[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[CH:29][CH:28]=2)[CH:23]=[CH:22]1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:19][C:31](=[O:32])[C:30]1[CH:29]=[CH:28][C:27]([C:24]2[CH:23]=[CH:22][C:21](=[O:20])[NH:26][CH:25]=2)=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 532177425-(4-Carboxyphenyl)-2-hydroxypyridineHCID 594018302-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 59401802N-[2-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzamide

Procedure

The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 4-(6-oxo-1,6-dihydro-pyridin-3-yl)-benzoic acid. MS: 457.3 (M+H).

Sources & evidence

ORD record
ord-7e56ba513bbe442b988ee2ebf52f9a75
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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