4-(1-Imidazolyl)benzoic Acid → 4-Imidazol-1-yl-N-[2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-benzamide

HRID 1916957Notes

Reaction equation

HRID 1916957 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[N:20]1([C:25]2[CH:33]=[CH:32][C:28]([C:29](O)=[O:30])=[CH:27][CH:26]=2)[CH:24]=[CH:23][N:22]=[CH:21]1>>[N:20]1([C:25]2[CH:26]=[CH:27][C:28]([C:29]([NH:19][C:3]3[CH:4]=[CH:5][C:6]([N:8]4[CH2:12][CH2:11][CH:10]([N:13]5[CH2:17][CH2:16][CH2:15][CH:14]5[CH3:18])[CH2:9]4)=[CH:7][C:2]=3[CH3:1])=[O:30])=[CH:32][CH:33]=2)[CH:24]=[CH:23][N:22]=[CH:21]1

Participants

3

Reactant 2

HCID 7365294-(1-Imidazolyl)benzoic AcidHCID 594018302-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 594018244-Imidazol-1-yl-N-[2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-benzamide

Procedure

The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 4-imidazol-1-yl benzoic acid. MS: 430.5 (M+H).

Sources & evidence

ORD record
ord-7a75a5c76ce945e785dc680b317b8451
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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