HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917064Generated: October 30, 2026
Formaldehyde → Methyl hydroxymethyl(2-(4-methoxyphenylthio)ethyl)carbamate
https://huagongshe.com/reaction/1917064
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methyl 2-(4-methoxyphenylthio)ethylcarbamate | HCID 57864658 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl hydroxymethyl(2-(4-methoxyphenylthio)ethyl)carbamate | HCID 57864666 | — |
Reaction Steps
A mixture of compound 7 (2.0 g), paraformaldehyde (1.5 g), Cs2CO3 (1.2 eq.) in THF (50 mL) was stirred at 70° C. for 3 hours. Filtration and concentration of the solvent gave the title product 9 as pure white solid. Yield: 2.2 g, 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08618282B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-4d9b234d2847477695bb763e7c762975 |
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| Source note | uspto-grants-2013_12 |
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