HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917066Generated: November 1, 2026
Acetyl chloride → N-(2-(4-methoxyphenylthio)ethyl)acetamide
https://huagongshe.com/reaction/1917066
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(4-Methoxyphenylthio)ethanamine hydrochloride | HCID 12261933 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-(4-methoxyphenylthio)ethyl)acetamide | HCID 49865266 | — |
Reaction Steps
To a solution of compound 1-HCl (0.44 g) in CH2Cl2 (15 mL) cooled to ˜0° C. was added acetyl chloride (1.0 mL) and triethylamine (1.0 mL). The reaction mixture was stirred for 1 hour at 0° C. and washed with 1N HCl, sat. NaHCO3. The solvents were removed by evaporation under reduced pressure to give product 10 as solid (pure by TLC and NMR). Yield: 0.5 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618282B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-9e9f51fbe6684a45be1b76f13041ff09 |
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| Source note | uspto-grants-2013_12 |
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