HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917069Generated: November 3, 2026
Formaldehyde → 7-Methoxy-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carbaldehyde
https://huagongshe.com/reaction/1917069
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | N-(2-(4-Methoxyphenylthio)ethyl)formamide | HCID 57864671 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 7-Methoxy-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carbaldehyde | HCID 57864672 | 70% |
Reaction Steps
A mixture of compound 14 (100 mg), paraformaldehyde (100 mg), p-toluenesulfonic acid (60 mg) in benzene (5 mL) was stirred at 70-75° C. for 2 days. Filtration, washing with sat. NaHCO3 and concentration gave crude product 15 in an estimated yield of ˜70% by TLC and NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618282B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-8099296a4cc14145b34d3b0779eb80df |
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| Source note | uspto-grants-2013_12 |
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