HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917082Generated: October 31, 2026
Formaldehyde → 1-(7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)prop-2-en-1-one
https://huagongshe.com/reaction/1917082
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | N-(2-(4-Methoxyphenylthio)ethyl)acrylamide | HCID 57864668 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1-(7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)prop-2-en-1-one | HCID 11391024 | — |
Reaction Steps
A mixture of compound 32 (280 mg), paraformaldehyde (600 mg), p-toluenesulfonic acid (140 mg) in benzene (7.0 mL) was stirred at 80° C. for 16 h. The reaction mixture was filtered and washed with sat. NaHCO3 solution (2×3 mL). The solvents were removed by evaporation under reduced pressure to give product 33 as an oil. Yield: 253 mg, 86%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618282B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-68d546a2063d4c7aac7ce93ac4a565f2 |
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| Source note | uspto-grants-2013_12 |
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