反应详情

温度

80 °C

A mixture of compound 32 (280 mg), paraformaldehyde (600 mg), p-toluenesulfonic acid (140 mg) in benzene (7.0 mL) was stirred at 80° C. for 16 h. The reaction mixture was filtered and washed with sat. NaHCO3 solution (2×3 mL). The solvents were removed by evaporation under reduced pressure to give product 33 as an oil. Yield: 253 mg, 86%.

1. filtrationThe reaction mixture was filtered
2. washwashed with sat. NaHCO3 solution (2×3 mL)
3. customThe solvents were removed by evaporation under reduced pressure