5-Bromouracil → 6-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione

HRID 1917085Notes

Reaction equation

[Br:1][C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6](C)[CH:7]=1.BrC1C(=O)[NH:15]C(=O)NC=1>>[Br:1][C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:7])[N:15]=1

Participants

Reactant 2

HCID 58025-Bromouracil

HCID 814945-Bromo-1,3-dimethyluracil

Product 1

HCID 2605636-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dioneYield 82%

Procedure

Synthesis of the intermediate 1c is achieved from 5-bromo-1H-pyrimidine-2,4-dione according to the operating procedure described for the synthesis of 1b (solid, yield 82%).

Sources & evidence

ORD record: ord-9096d8b0b2dc43559c194a5cc87be80f
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618287B2

Reaction notes

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