2-Methylpiperazine → 2,4-dimethyl-6-(piperazin-1-yl)-1,2,4-triazine-3,5(2H,4H)-dione

HRID 1917092Notes

Reaction equation

[CH3:1][N:2]1[C:7](=[O:8])[N:6]([CH3:9])[C:5](=[O:10])[C:4]([N:11]2[CH2:16][CH2:15][NH:14][CH:13](C)[CH2:12]2)=[N:3]1.CC1CNCCN1>>[CH3:1][N:2]1[C:7](=[O:8])[N:6]([CH3:9])[C:5](=[O:10])[C:4]([N:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)=[N:3]1

Participants

Reactant 2

HCID 660572-Methylpiperazine

HCID 582698052,4-dimethyl-6-(3-methyl-piperazin-1-yl)-2H-[1,2,4]triazine-3,5-dione

Product 1

HCID 337810652,4-dimethyl-6-(piperazin-1-yl)-1,2,4-triazine-3,5(2H,4H)-dioneYield 58%

Procedure

The synthesis of the intermediate 12c is achieved from 2-methyl-piperazine according to the operating procedure described for the synthesis of 12a (solid, yield: 58%).

Sources & evidence

ORD record: ord-e0c55aa453b0409fb9f90ebb8df73fa8
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08618287B2

Reaction notes

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