1-(2-Trifluoromethylbenzoyl)piperazine hydrochloride → Toluene

HRID 1917095Notes

Reaction equation

HRID 1917095 reaction equation
Br[C:2]1[C:3](=[O:10])[NH:4][C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.Cl.[N:12]1([C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]([F:29])([F:28])[F:27])=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[CH3:8][N:6]1[C:5](=[O:9])[NH:4][C:3](=[O:10])[C:2]([N:15]2[CH2:16][CH2:17][N:12]([C:18](=[O:19])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]([F:29])([F:27])[F:28])[CH2:13][CH2:14]2)=[N:7]1.[C:20]1([CH3:18])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 167337831-(2-Trifluoromethylbenzoyl)piperazine hydrochlorideHCID 582698136-bromo-2-methyl-2H-[1,2,4]triazine-3,5-dione

Product 2

HCID 1140TolueneYield 25%HCID 446214942-methyl-6-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2H-[1,2,4]triazine-3,5-dione

Procedure

The compound 2 (yellow powder) is prepared from the triazine 2e and from the intermediate 6a according to the synthesis method 1 in toluene (yield: 25%).

Sources & evidence

ORD record
ord-7d433ef3aee641e89a6ab149821dffd7
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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