6-bromo-4-methyl-1,2,4-triazine-3,5(2h,4h)-dione → Toluene

HRID 1917097Notes

Reaction equation

HRID 1917097 reaction equation
Br[C:2]1[C:3](=[O:10])[N:4]([CH3:9])[C:5](=[O:8])[NH:6][N:7]=1.Cl.[N:12]1([C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]([F:29])([F:28])[F:27])=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[CH3:9][N:4]1[C:3](=[O:10])[C:2]([N:15]2[CH2:16][CH2:17][N:12]([C:18](=[O:19])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]([F:29])([F:27])[F:28])[CH2:13][CH2:14]2)=[N:7][NH:6][C:5]1=[O:8].[C:20]1([CH3:18])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 2605646-bromo-4-methyl-1,2,4-triazine-3,5(2h,4h)-dioneHCID 167337831-(2-Trifluoromethylbenzoyl)piperazine hydrochloride

Product 2

HCID 1140TolueneYield 27%HCID 446214964-methyl-6-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2H-[1,2,4]triazine-3,5-dione

Procedure

The compound 4 (solid) is prepared from the triazine 2a and the intermediate 6a according to the synthesis method 1 in toluene (yield: 27%).

Sources & evidence

ORD record
ord-93af7624adb948a9833888fe21881cf8
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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