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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917097Generated: November 1, 2026

6-bromo-4-methyl-1,2,4-triazine-3,5(2h,4h)-dione → Toluene

https://huagongshe.com/reaction/1917097

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-bromo-4-methyl-1,2,4-triazine-3,5(2h,4h)-dioneHCID 260564—
Reactant1-(2-Trifluoromethylbenzoyl)piperazine hydrochlorideHCID 16733783—
ProductTolueneHCID 114027%
Product4-methyl-6-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2H-[1,2,4]triazine-3,5-dioneHCID 44621496—

Reaction Steps

The compound 4 (solid) is prepared from the triazine 2a and the intermediate 6a according to the synthesis method 1 in toluene (yield: 27%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08618287B2
Source datasetuspto-grants-2013_12
ORD IDord-93af7624adb948a9833888fe21881cf8
Source noteuspto-grants-2013_12