6-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione → Toluene
Reaction equation
Br[C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.Cl.[N:13]1([C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[C:27]([F:30])([F:29])[F:28])=[O:20])[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[CH3:8][N:6]1[C:5](=[O:9])[N:4]([CH3:10])[C:3](=[O:11])[C:2]([N:16]2[CH2:17][CH2:18][N:13]([C:19](=[O:20])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([F:30])([F:28])[F:29])[CH2:14][CH2:15]2)=[N:7]1.[C:21]1([CH3:19])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1Participants
4
Procedure
The compound 5 (solid) is prepared from the triazine 1b and the intermediate 6a according to the synthesis method 1 in toluene (yield: 55%).
Sources & evidence
- ORD record
- ord-5d595c5838814334aba6ea04c9e257df
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08618287B2
Reaction notes
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