1-(3-(Trifluoromethyl)phenyl)piperazine → 1-Butanol

HRID 1917100Notes

Reaction equation

HRID 1917100 reaction equation
Br[C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[F:12][C:13]([F:27])([F:26])[C:14]1[CH:15]=[C:16]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:17]=[CH:18][CH:19]=1>>[CH2:3]([OH:11])[CH2:2][CH2:13][CH3:14].[CH3:8][N:6]1[C:5](=[O:9])[N:4]([CH3:10])[C:3](=[O:11])[C:2]([N:23]2[CH2:22][CH2:21][N:20]([C:16]3[CH:17]=[CH:18][CH:19]=[C:14]([C:13]([F:26])([F:27])[F:12])[CH:15]=3)[CH2:25][CH2:24]2)=[N:7]1

Participants

4

Reactant 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 2605636-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione

Product 2

HCID 2631-ButanolYield 63%HCID 582697612,4-dimethyl-6-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-2H-[1,2,4]triazine-3,5-dione

Procedure

The compound 7 (solid) is prepared from the triazine 1b and from 1-(3-trifluoromethyl-phenyl)-piperazine according to the synthesis method 1 in n-butanol (yield: 63%).

Sources & evidence

ORD record
ord-3725c290575a4af3a2f6e1ae9b534903
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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