1-(3-(Trifluoromethyl)phenyl)piperazine → 1-Butanol

HRID 1917101Notes

Reaction equation

HRID 1917101 reaction equation
Br[C:2]1[C:3](=[O:17])[N:4]([CH3:16])[C:5](=[O:15])[N:6]([CH2:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])[N:7]=1.[F:18][C:19]([F:33])([F:32])[C:20]1[CH:21]=[C:22]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:23]=[CH:24][CH:25]=1>>[CH2:24]([OH:15])[CH2:25][CH2:20][CH3:19].[CH3:16][N:4]1[C:3](=[O:17])[C:2]([N:29]2[CH2:28][CH2:27][N:26]([C:22]3[CH:23]=[CH:24][CH:25]=[C:20]([C:19]([F:32])([F:33])[F:18])[CH:21]=3)[CH2:31][CH2:30]2)=[N:7][N:6]([CH2:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])[C:5]1=[O:15]

Participants

4

Reactant 2

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 59298833HCID 59298833, compound

Product 2

HCID 2631-ButanolYield 76%HCID 582697754-methyl-2-(4,4,4-trifluoro-butyl)-6-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-2H-[1,2,4]triazine-3,5-dione

Procedure

The compound 8 (oil) is prepared from the triazine 4a and from 1-(3-trifluoromethyl-phenyl)-piperazine according to the synthesis method 1 in n-butanol (yield: 76%).

Sources & evidence

ORD record
ord-00a77678ef324cd6bdeef1cea5417d7d
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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