Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917101Generated: November 1, 2026

1-(3-(Trifluoromethyl)phenyl)piperazine → 1-Butanol

https://huagongshe.com/reaction/1917101

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-(Trifluoromethyl)phenyl)piperazineHCID 4296—
Reactant6-Bromo-4-methyl-2-(4,4,4-trifluoro-butyl)-2H-[1,2,4]triazine-3,5-dioneHCID 59298833—
Product1-ButanolHCID 26376%
Product4-methyl-2-(4,4,4-trifluoro-butyl)-6-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-2H-[1,2,4]triazine-3,5-dioneHCID 58269775—

Reaction Steps

The compound 8 (oil) is prepared from the triazine 4a and from 1-(3-trifluoromethyl-phenyl)-piperazine according to the synthesis method 1 in n-butanol (yield: 76%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08618287B2
Source datasetuspto-grants-2013_12
ORD IDord-00a77678ef324cd6bdeef1cea5417d7d
Source noteuspto-grants-2013_12