1-[2-(Trifluoromethyl)phenyl]piperazine → 1-Butanol

HRID 1917102Notes

Reaction equation

HRID 1917102 reaction equation
Br[C:2]1[C:3](=[O:17])[N:4]([CH3:16])[C:5](=[O:15])[N:6]([CH2:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])[N:7]=1.[F:18][C:19]([F:33])([F:32])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH2:22]([OH:15])[CH2:21][CH2:20][CH3:19].[CH3:16][N:4]1[C:3](=[O:17])[C:2]([N:29]2[CH2:28][CH2:27][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[C:19]([F:32])([F:33])[F:18])[CH2:31][CH2:30]2)=[N:7][N:6]([CH2:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])[C:5]1=[O:15]

Participants

4

Reactant 2

HCID 27776701-[2-(Trifluoromethyl)phenyl]piperazineHCID 59298833HCID 59298833, compound

Product 2

HCID 2631-ButanolYield 82%HCID 58269812HCID 58269812, compound

Procedure

The compound 9 (solid) is prepared from the triazine 4a and from 1-(2-trifluoromethyl-phenyl)-piperazine according to the synthesis method 1 in n-butanol (yield: 82%).

Sources & evidence

ORD record
ord-8cd52c2675624ed1be8e3da84a1ac629
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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