4-(2-Chlorophenoxy)piperidine → 1-Butanol

HRID 1917104Notes

Reaction equation

HRID 1917104 reaction equation
Br[C:2]1[C:3](=[O:14])[N:4]([CH3:13])[C:5](=[O:12])[N:6]([CH2:8][CH2:9][C:10]#[N:11])[N:7]=1.[Cl:15][C:16]1[CH:28]=[CH:27][CH:26]=[CH:25][C:17]=1[O:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Cl:15][C:16]1[CH:28]=[CH:27][CH:26]=[CH:25][C:17]=1[O:18][CH:19]1[CH2:24][CH2:23][N:22]([C:2]2[C:3](=[O:14])[N:4]([CH3:13])[C:5](=[O:12])[N:6]([CH2:8][CH2:9][C:10]#[N:11])[N:7]=2)[CH2:21][CH2:20]1.[CH2:17]([OH:18])[CH2:16][CH2:28][CH3:27]

Participants

4

Reactant 2

HCID 38646564-(2-Chlorophenoxy)piperidineHCID 592988283-(6-Bromo-4-methyl-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-propionitrile

Product 2

HCID 2631-ButanolYield 58%HCID 446215053-{6-[4-(2-chloro-phenoxy)-piperidin-1-yl]-4-methyl-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl}-propionitrile

Procedure

The compound 23 (oil) is prepared from the triazine 3a and from the intermediate 8a according to the synthesis method 1 in n-butanol (yield: 58%).

Sources & evidence

ORD record
ord-cc18df5ada954d15b4b39af78811904c
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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