6-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione → 1-Butanol

HRID 1917107Notes

Reaction equation

HRID 1917107 reaction equation
Br[C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[Cl:12][C:13]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:14]=1[O:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[Cl:12][C:13]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][C:14]=1[O:15][CH:16]1[CH2:17][CH2:18][N:19]([C:2]2[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=2)[CH2:20][CH2:21]1.[CH2:14]([OH:15])[CH2:13][CH2:25][CH3:24]

Participants

4

Reactant 2

HCID 2605636-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dioneHCID 167327414-(2-Chloro-5-fluorophenoxy)piperidine

Product 2

HCID 2631-ButanolYield 77%HCID 446215106-[4-(2-chloro-5-fluoro-phenoxy)-piperidin-1-yl]-2,4-dimethyl-2H-[1,2,4]triazine-3,5-dione

Procedure

The compound 30 (solid) is prepared from the triazine 1b and from the intermediate 8b according to the synthesis method 1 in n-butanol (yield: 77%).

Sources & evidence

ORD record
ord-50cef200d2f245c9998e209b0561f24e
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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