5-Bromo-1,3-dimethyluracil → 1-Butanol

HRID 1917108Notes

Reaction equation

HRID 1917108 reaction equation
Br[C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[Cl:12][C:13]1[CH:25]=[CH:24][CH:23]=[CH:22][C:14]=1[O:15][CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[Cl:12][C:13]1[CH:25]=[CH:24][CH:23]=[CH:22][C:14]=1[O:15][CH:16]1[CH2:21][CH2:20][N:19]([C:2]2[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=2)[CH2:18][CH2:17]1.[CH2:14]([OH:15])[CH2:13][CH2:25][CH3:24]

Participants

4

Reactant 2

HCID 814945-Bromo-1,3-dimethyluracilHCID 38646564-(2-Chlorophenoxy)piperidine

Product 2

HCID 2631-ButanolYield 17%HCID 582697765-[4-(2-chloro-phenoxy)-piperidin-1-yl]-1,3-dimethyl-1H-pyrimidine-2,4-dione

Procedure

The compound 35 (oil) is prepared from the uracil 1c and from the intermediate 8a according to the synthesis method 1 in n-butanol (yield: 17%).

Sources & evidence

ORD record
ord-f1380917353f47e297d8fafe1ee180f1
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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