6-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione → 1-Butanol

HRID 1917109Notes

Reaction equation

HRID 1917109 reaction equation
Br[C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[F:12][C:13]([F:27])([F:26])[C:14]1[CH:25]=[CH:24][CH:23]=[CH:22][C:15]=1[O:16][CH:17]1[CH2:21][CH2:20][NH:19][CH2:18]1>>[CH3:8][N:6]1[C:5](=[O:9])[N:4]([CH3:10])[C:3](=[O:11])[C:2]([N:19]2[CH2:20][CH2:21][CH:17]([O:16][C:15]3[CH:22]=[CH:23][CH:24]=[CH:25][C:14]=3[C:13]([F:12])([F:27])[F:26])[CH2:18]2)=[N:7]1.[CH2:15]([OH:16])[CH2:14][CH2:25][CH3:24]

Participants

4

Reactant 2

HCID 2605636-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dioneHCID 450754873-[2-(Trifluoromethyl)phenoxy]pyrrolidine

Product 2

HCID 2631-ButanolYield 60%HCID 582697942,4-dimethyl-6-[3-(2-trifluoromethyl-phenoxy)-pyrrolidin-1-yl]-2H-[1,2,4]triazine-3,5-dione

Procedure

The compound 37 (solid) is prepared from the triazine 1b and from the intermediate 11a according to the synthesis method 1 in n-butanol (yield: 60%).

Sources & evidence

ORD record
ord-6bff831ede6d4c909a7741940725d4f3
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

Loading…