6-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione → 1-Butanol

HRID 1917110Notes

Reaction equation

HRID 1917110 reaction equation
Br[C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[O:12]([CH:19]1[CH2:23][CH2:22][NH:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH3:8][N:6]1[C:5](=[O:9])[N:4]([CH3:10])[C:3](=[O:11])[C:2]([N:21]2[CH2:22][CH2:23][CH:19]([O:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:20]2)=[N:7]1.[CH2:13]([OH:12])[CH2:14][CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 2605636-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dioneHCID 144973523-Phenoxypyrrolidine

Product 2

HCID 2631-ButanolYield 72%HCID 582697882,4-dimethyl-6-(3-phenoxy-pyrrolidin-1-yl)-2H-[1,2,4]triazine-3,5-dione

Procedure

The compound 38 (solid) is prepared from the triazine 1b and from the intermediate 11b according to the synthesis method 1 in n-butanol (yield: 72%).

Sources & evidence

ORD record
ord-e7ac4286367a47408cfcc6e734658efb
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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