HRID1917113

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2737560

5-Fluoro-2-(trifluoromethyl)benzoyl chloride

C8H3ClF4O

HCID33781065

未命名化合物

PRODUCTS

生成物

结构：Cn1nc(N2CCN(C(=O)c3cc(F)ccc3C(F)(F)F)CC2)c(=O)n(C)c1=O

HCID44621530

未命名化合物

结构：Cn1nc(N2CCN(C(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)CC2)c(=O)n(C)c1=O

HCID58269815

未命名化合物

收率 86%

PROCEDURE

实验过程

The compound 42 (solid) is prepared from 5-fluoro-2-trifluoromethyl-benzoyl chloride and from the intermediate 12a according to the synthesis method 2 under the operating conditions described for Example 40 (yield: 86%).

WORKUP

后处理

customaccording to the synthesis method 2 under the operating conditions

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4da9623dfe8f4733be1a7e8b7621800d
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08618287B2
来源说明: uspto-grants-2013_12

反应 SMILES

[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]([F:14])([F:13])[F:12])=[C:6]([CH:10]=1)[C:7](Cl)=[O:8].[CH3:15][N:16]1[C:21](=[O:22])[N:20]([CH3:23])[C:19](=[O:24])[C:18]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:17]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]([F:14])([F:13])[F:12])=[C:6]([CH:10]=1)[C:7]([N:28]1[CH2:27][CH2:26][N:25]([C:18]2[C:19](=[O:24])[N:20]([CH3:23])[C:21](=[O:22])[N:16]([CH3:15])[N:17]=2)[CH2:30][CH2:29]1)=[O:8].[F:12][C:11]([F:14])([F:13])[C:5]1[CH:4]=[CH:3][C:2]([C:11]([F:14])([F:13])[F:12])=[CH:10][C:6]=1[C:7]([N:28]1[CH2:27][CH2:26][N:25]([C:18]2[C:19](=[O:24])[N:20]([CH3:23])[C:21](=[O:22])[N:16]([CH3:15])[N:17]=2)[CH2:30][CH2:29]1)=[O:8]