HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-(trifluoromethyl)benzoyl chloride → 6-[4-(2,5-Bis-trifluoromethyl-benzoyl)-piperazin-1-yl]-2,4-dimethyl-2H-[1,2,4]triazine-3,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-(trifluoromethyl)benzoyl chloride | HCID 2737560 | — |
| Reactant | 2,4-dimethyl-6-(piperazin-1-yl)-1,2,4-triazine-3,5(2H,4H)-dione | HCID 33781065 | — |
| Product | 6-[4-(5-fluoro-2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2,4-dimethyl-2H-[1,2,4]triazine-3,5-dione | HCID 44621530 | — |
| Product | 6-[4-(2,5-Bis-trifluoromethyl-benzoyl)-piperazin-1-yl]-2,4-dimethyl-2H-[1,2,4]triazine-3,5-dione | HCID 58269815 | 86% |
Reaction Steps
The compound 42 (solid) is prepared from 5-fluoro-2-trifluoromethyl-benzoyl chloride and from the intermediate 12a according to the synthesis method 2 under the operating conditions described for Example 40 (yield: 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618287B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-4da9623dfe8f4733be1a7e8b7621800d |
| Source note | uspto-grants-2013_12 |