4-(2-Chloro-5-fluorophenoxy)piperidine → 6-(4-(2-chloro-5-fluorophenoxy)piperidin-1-yl)-2-methyl-1,2,4-triazine-3,5(2H, 4H)-dione

HRID 1917118Notes

Reaction equation

HRID 1917118 reaction equation
Br[C:2]1[C:3](=[O:10])[NH:4][C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[Cl:11][C:12]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:13]=1[O:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>C1(C)C=CC=CC=1>[Cl:11][C:12]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:13]=1[O:14][CH:15]1[CH2:16][CH2:17][N:18]([C:2]2[C:3](=[O:10])[NH:4][C:5](=[O:9])[N:6]([CH3:8])[N:7]=2)[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 167327414-(2-Chloro-5-fluorophenoxy)piperidineHCID 582698136-bromo-2-methyl-2H-[1,2,4]triazine-3,5-dione

Product 1

HCID 582697556-(4-(2-chloro-5-fluorophenoxy)piperidin-1-yl)-2-methyl-1,2,4-triazine-3,5(2H, 4H)-dione

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The compound 90 (white powder) is prepared from the triazine 2e and from the intermediate 8b according to the synthesis method 1 in toluene.

Sources & evidence

ORD record
ord-22a6e705493244b1b056be0564d539e5
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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