4-(2,5-Dichlorophenoxy)piperidine → 4-(2-Chlorophenoxy)piperidine

HRID 1917119Notes

Reaction equation

HRID 1917119 reaction equation
Br[C:2]1[C:3](=[O:10])[NH:4][C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[Cl:11][C:12]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:13]=1[O:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>>[Cl:11][C:12]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:13]=1[O:14][CH:15]1[CH2:16][CH2:17][N:18]([C:2]2[C:3](=[O:10])[NH:4][C:5](=[O:9])[N:6]([CH3:8])[N:7]=2)[CH2:19][CH2:20]1.[Cl:11][C:12]1[CH:24]=[CH:23][CH:22]=[CH:21][C:13]=1[O:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 167316964-(2,5-Dichlorophenoxy)piperidineHCID 582698136-bromo-2-methyl-2H-[1,2,4]triazine-3,5-dione

Product 2

HCID 38646564-(2-Chlorophenoxy)piperidineHCID 582697986-(4-(2,5-dichlorophenoxy)piperidin-1-yl)-2-methyl-1,2,4-triazine-3,5(2H, 4H)-dione

Procedure

The compound 91 (white solid) is prepared from the triazine 2e and from 4-(2,5-dichlorophenoxy)piperidine (obtained as under the preparative methods of intermediate 8a) according to the synthesis method 1 in toluene.

Sources & evidence

ORD record
ord-6c04e01d360d4ec2b1661f9c01e573ec
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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