6-bromo-2-methyl-2H-[1,2,4]triazine-3,5-dione → 4-(2-Chlorophenoxy)piperidine

HRID 1917120Notes

Reaction equation

HRID 1917120 reaction equation
Br[C:2]1[C:3](=[O:10])[NH:4][C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[Br:11][C:12]1[CH:13]=[CH:14][C:15]([Cl:25])=[C:16]([CH:24]=1)[O:17][CH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[Br:11][C:12]1[CH:13]=[CH:14][C:15]([Cl:25])=[C:16]([CH:24]=1)[O:17][CH:18]1[CH2:19][CH2:20][N:21]([C:2]2[C:3](=[O:10])[NH:4][C:5](=[O:9])[N:6]([CH3:8])[N:7]=2)[CH2:22][CH2:23]1.[Cl:25][C:15]1[CH:14]=[CH:13][CH:12]=[CH:24][C:16]=1[O:17][CH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

4

Reactant 2

HCID 582698136-bromo-2-methyl-2H-[1,2,4]triazine-3,5-dioneHCID 640112854-(5-Bromo-2-chlorophenoxy)piperidine

Product 2

HCID 38646564-(2-Chlorophenoxy)piperidineHCID 582697816-(4-(5-bromo-2-chlorophenoxy)piperidin-1-yl)-2-methyl-1,2,4-triazine-3,5(2H, 4H)-dione

Procedure

The compound 92 (yellow powder) is prepared from the triazine 2e and from 4-(5-bromo-2-chlorophenoxy)piperidine (obtained as under the preparative conditions of intermediate 8a) according to the synthesis method 1 in toluene.

Sources & evidence

ORD record
ord-e717bfc2cd5d40ca8ffcc926abcd6d90
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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