Hydrochloric Acid → N-(4-(2-(Dimethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thiophene-2-carboximidamide dihydrochloride

HRID 1917150Notes

Reaction equation

HRID 1917150 reaction equation
[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][C:7]2[CH:11]=[CH:12][C:13]([NH:15][C:16]([C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)=[NH:17])=[CH:14][C:6]1=2.[ClH:24]>CO>[ClH:24].[ClH:24].[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][C:7]2[CH:11]=[CH:12][C:13]([NH:15][C:16]([C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)=[NH:17])=[CH:14][C:6]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178483710HCID 178483710, compound

Product 1

HCID 178483711N-(4-(2-(Dimethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thiophene-2-carboximidamide dihydrochlorideYield 73.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(4-(2-(dimethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)thiophene-2-carboximidamide (0.065 g, 0.197 mmol) was dissolved in anhydrous MeOH (5 mL) and treated with hydrogen chloride (1M in diethyl ether; 0.433 mL, 0.433 mmol) for 5 minutes at room temperature. The reaction was then concentrated to yield the title compound as a yellow solid (58.5 mg, 73.7%). 1H NMR (DMSO-d6) δ 11.36 (brs, 1H), 11.02 (brs, 1H), 9.70 (brs, 1H), 8.69 (brs, 1H), 8.15 (app d, 2H, J=4.5 Hz), 7.37 (app t, 1H, J=4.3 Hz), 7.07 (s, 1H), 6.84 (d, 1H, J=8.3 Hz), 6.62 (d, 1H, J=8.4 Hz), 4.31-4.18 (m, 2H), 3.76-3.65 (m, 2H), 3.44-3.34 (m, 2H), 3.35-3.22 (m, 2H), 2.78, 2.77 (2×s, 6H); ESI-MS (m/z, %): 331 (MH+, free base, 100); ESI-HRMS calculated for C17H23N4OS (MH+, free base): 331.1587; observed: 331.1579.

Workup

  1. concentrationThe reaction was then concentrated

Sources & evidence

ORD record
ord-c79fe8f7e13a4ec3a3fdb9a1e13b0da9
Source dataset
uspto-grants-2013_12
Patent number
US08618286B2

Reaction notes

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