Hydrochloric Acid → HCID 178464395, compound

HRID 1917253Notes

Reaction equation

HRID 1917253 reaction equation
[CH2:1]([NH:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][S:9][C:8]2[CH:12]=[C:13]([NH:16][C:17]([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)=[NH:18])[CH:14]=[CH:15][C:7]1=2)[CH3:2].[ClH:24]>CO>[ClH:24].[ClH:24].[CH2:1]([NH:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][S:9][C:8]2[CH:12]=[C:13]([NH:16][C:17]([C:19]3[S:20][CH:21]=[CH:22][CH:23]=3)=[NH:18])[CH:14]=[CH:15][C:7]1=2)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178464394HCID 178464394, compound

Product 1

HCID 178464395HCID 178464395, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of N-(4-(2-(ethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)thiophene-2-carboximidamide (0.142 g, 0.410 mmol) in dry methanol (5 mL) was treated with hydrochloric acid (1M in ether; 2.049 mL, 2.049 mmol) and stirred at room temperature for 1 hour. The reaction was then concentrated to give a yellow solid. 1H-NMR (DMSO-d6) δ 11.22 (brs, 1H) 9.68 (brs, 1H), 9.32 (brs, 2H), 8.69 (brs, 1H), 8.15-8.11 (m, 2H), 7.36 (pseudo t, J=7.2 Hz, 1H), 7.06-6.99 (m, 3H), 3.70-3.60 (overlap with solvent peak, m, 4H), 3.12-3.02 (m, 4H), 3.02-2.93 (m, 2H), 1.23 (t, J=7.2 Hz, 3H).

Workup

  1. concentrationThe reaction was then concentrated
  2. customto give a yellow solid

Sources & evidence

ORD record
ord-18c65e5da7894e018dd7b599c0aa3538
Source dataset
uspto-grants-2013_12
Patent number
US08618286B2

Reaction notes

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