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A solution of crude 1-(3,4,5,6,3′,6′-hexahydro-2H,2′H-[1,4′]bipyridinyl-1′-yl)-ethanone in CH2Cl2 (1.5 L) was treated with Et3N (108 mL, 0.78 mol) and then cooled to 0° C. A solution of 4-fluorobenzoyl chloride (107 g, 0.68 mol) in CH2Cl2 (150 mL) was added over 1 h. The reaction mixture was stirred at rt for 2 h, then was concentrated to give a crude material which was directly used on next reaction. HPLC: RT=7.52 min. MS (ESI): exact mass calcd. for C19H23FN2O2, 330.17; m/z found, 331.0 [M+H]+.

1. concentrationwas concentrated