HCID 67490881, compound → HCID 67490863, compound

HRID 1917430Notes

Reaction equation

HRID 1917430 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@:9]12[CH2:16][CH2:15][CH2:14][C@@:13]1([Cl:17])[CH2:12][N:11]([C@@H](C1C=CC=CC=1)C)[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]([NH:8][C@@:9]12[CH2:16][CH2:15][CH2:14][C@@:13]1([Cl:17])[CH2:12][NH:11][CH2:10]2)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 67490881HCID 67490881, compound

Product 1

HCID 67490863HCID 67490863, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

Under hydrogen atmosphere, a mixture of (1R,5R)-1-(tert-butoxycarbonylamino)-5-chloro-3-[(1R)-1-phenylethyl]-3-azabicyclo[3.3.0]octane (63.0 mg, 0.173 mmol), 10% Pd—C (50 wt %, M, 32 mg) in methanol (6 mL) was stirred for 4 hours at room temperature and for 19 hours at 40° C. After removing catalyst by filtration, the filtrate was distilled off under reduced pressure.

Workup

  1. customAfter removing catalyst
  2. filtrationby filtration
  3. distillationthe filtrate was distilled off under reduced pressure

Sources & evidence

ORD record
ord-0ca7d3ba01ac4dc7a624f20ab74daf08
Source dataset
uspto-grants-2013_12
Patent number
US08618094B2

Reaction notes

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