HCID 67490881, compound → HCID 67490863, compound

Participants

Reaction Conditions

Reaction Steps

Under hydrogen atmosphere, a mixture of (1R,5R)-1-(tert-butoxycarbonylamino)-5-chloro-3-[(1R)-1-phenylethyl]-3-azabicyclo[3.3.0]octane (63.0 mg, 0.173 mmol), 10% Pd—C (50 wt %, M, 32 mg) in methanol (6 mL) was stirred for 4 hours at room temperature and for 19 hours at 40° C. After removing catalyst by filtration, the filtrate was distilled off under reduced pressure.

Provenance & Evidence